In 1989 a group of Serowe residents conceived the idea of a wildlife reserve near Serowe. The land around Serwe Pan, then a cattle-post, was allocated to the Khama Rhino Sanctuary Trust by the Ngwato Land Board in 1993.

Khama Rhino Sanctuary lies 25km north of Serowe on the road to Orapa. Covering approximately 4,300 hectares of Kalahari sandveld, including several natural water holes, the Sanctuary provides prime habitat for white rhinoceros and many other species of animals and birds. The Botswana Defence Force (BDF) provides 24 hour protection against poachers.

The Sanctuary is a community trust which is governed by a Board of Trustees who are elected from the local communities of Serowe, Paje and Mabeleapodi. Serowe is one of the largest traditional villages in Africa and is the birthplace of Botswana's first President, the late Sir Seretse Khama. Paje and Mabeleapodi are two small picturesque villages close to the Sanctuary. The Vice President of Botswana, Lt. Gen.S.K.I. Khama, Paramount Chief of the Bamangwato, is Patron of the Trust. Khama Rhino Sanctuary.